I have quite successfully used Radiesse and Sculptra treatments for different areas of the face in the same patient but I don't recommend injecting them simultaneously. I usually recommend injecting Radiesse first for the "instant" results which can then be followed by a series of Sculptra treatments at a future date to give longer-lasting results. I feel they each have certain advantages, when properly used, to fix volume loss in different areas of the face. Radiesse is gel-based and works best for cheeks, nasolabial folds, marionette lines and the jaw line. Sculptra is water-based so it is easier to place more diffusely underneath the skin. Sculptra also works well in the cheeks and especially the temples. It is my preferred treatment for fine lines due to volume loss throughout the lower face. Hyaluronic acid gels like Juvederm or Restylane are injected more superficially than either Sculptra or Radiesse so they can be used at the same time, if appropriate.