Microneedling increases collagen but decreases elastin?

Question

I read a paper (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509584) from 2015 about how micro needling can be used to treat atrophic acne scars. There was a statistically significant increase in collagen, decrease in total elastin, and enhancement of collagen and elastin deposition and formation. My understanding is that elastin is generally considered a good thing, which would suggest that a decrease in total elastin is a bad thing. How should I interpret this paper?

Anna Chacon, MD, FAAD · Answer

Understanding Microneedling's Impact on Collagen and Elastin

Microneedling is a popular dermatological procedure known for stimulating collagen production, which can improve the appearance of atrophic acne scars and overall skin texture. However, the findings you mentioned about changes in elastin may seem counterintuitive. Here's how to interpret these results:

1. Collagen vs. Elastin:
Collagen is a protein that provides structure and firmness to the skin, while elastin gives skin its elasticity and ability to return to its original shape after stretching.
An increase in collagen is generally beneficial for scar treatment and skin rejuvenation.

2. Understanding Elastin Changes:
The reported decrease in total elastin might refer to the breakdown of old, disorganized elastin fibers, which can occur as part of the skin's natural remodeling process.
Microneedling can stimulate the synthesis of new, more organized elastin fibers, which might not immediately reflect as an increase in total elastin but improve skin elasticity over time.

3. Interpreting the Study:
The study likely highlights a complex remodeling process where initial elastin breakdown is followed by new elastin formation. This process can lead to improved skin elasticity and appearance in the long term.
It's important to consider the context of the study, including methodology and the specific measurements used to assess elastin changes.

4. Clinical Implications:
The overall goal of microneedling is to improve skin structure and function, which can be achieved through increased collagen and the gradual remodeling of elastin.
Discussing these findings with a dermatologist can provide more personalized insight into how microneedling might work for your specific skin concerns.

In summary, while the initial decrease in total elastin might seem concerning, the procedure's long-term benefits typically include enhanced skin firmness and elasticity due to the remodeling of both collagen and elastin. Consulting with a dermatologist will help you understand these changes in the context of your skin's needs and treatment goals.

Microneedling increases collagen but decreases elastin?

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Microneedling increases collagen but decreases elastin?

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Everything you need to know about Microneedling

Our mission is to create a world where every investment in modern beauty is Worth It.