Hello Practical840070, and thank you for your question regarding the long-term risks of silicone 1000 microdroplet injections. Permanent fillers, including silicone 1000, carry significant long-term risks that may develop even years after treatment. While microdroplet techniques are designed to minimize complications, no amount of permanent filler is risk-free. Unlike temporary fillers, such as hyaluronic acid (HA), permanent fillers cannot be dissolved and must be surgically removed if complications arise. Some of the most common complications include: Migration: Silicone can shift from the original injection site, causing deformities or asymmetry. This is particularly concerning since it can migrate to critical areas, such as blood vessels or vital structures. Scar Tissue Formation: Silicone often triggers the body’s immune response, leading to the formation of fibrotic tissue. Over time, this can result in nodules, lumps, or severe hardening of the treated area. Necrosis and Organ Failure: Silicone particles can embolize, blocking blood flow and causing tissue death (necrosis). In severe cases, migration into vital organs can lead to systemic complications, including organ failure. ASIA Syndrome (Autoimmune Syndrome Induced by Adjuvants): Silicone is a known trigger for this condition, which occurs when the immune system overreacts to the filler material. Symptoms may include chronic fatigue, joint pain, swelling, and systemic inflammation, leading to a significant decline in quality of life. I specialize in the removal of permanent fillers and perform this procedure 5 to 7 times a week. Removal can be complex, involving risks of scarring, residual deformities, and damage to surrounding tissues. Despite this, removal is often necessary to prevent or address serious complications. While you have not experienced complications yet, it’s essential to monitor the treated areas closely. Symptoms like swelling, pain, redness, lumps, or changes in appearance should be evaluated immediately by a board-certified plastic surgeon or dermatologist experienced in permanent filler complications. If concerns arise, surgical removal of the silicone may be your safest option. I hope this helps clarify the risks and gives you the information you need to make informed decisions about your next steps. Sincerely, J. Timothy Katzen, MD