Can Polynucleotide Injections make a future facelift difficult?

These are important questions, and it’s good that you’re thinking ahead about how current treatments might influence future surgery. Polynucleotides, PDRN, exosomes, and similar regenerative products are relatively new, and their long-term effects on deeper facial tissues are not yet well defined. It would be wise to follow the evidence closely and wait until scientific results are more definitive. In general, they are intended to act more superficially, though evidence is still evolving. Some important factors: exactly which products were injected, the dosage, frequency, and depth of these injections.
If you end up considering a facelift in the future, what will matter most is whether these treatments have caused persistent inflammation, thickening, scarring, or changes in tissue quality. These details can only be assessed in person on physical examination. A consultation with a qualified plastic surgeon would help clarify whether your prior injections have any relevance for a future facelift, how that facelift could be modified to navigate any findings identified on exam or intraoperatively, and what approach would be safest based on your individual health, anatomy, and goals.

Hello! My name is Jessica, I am a physician assistant, and one of the providers at Aesthetic Skin - Winnetka & Chicago. This is a great question. No—polynucleotide injections do not make a future facelift difficult. These treatments work by improving skin quality, hydration, and cellular repair. They don’t add permanent volume, don’t create scar tissue in the deeper surgical planes, and don’t alter the anatomy a facelift surgeon works on (SMAS, fat pads, ligaments).

There are many new injectable treatments that are being used in the face and undereye area that we don't know much about, and some of them are not tested or approved for injection at all. While I do not believe the substances you mentioned will make a face lift more difficult (by nature of them not containing permanent or semi-permanent particulate matter), they may have other deleterious effects. I recommend asking your provider what the safety data is and if there are any long term studies on the products they are recommending.