You pose a good question and one that requires thought. The decision to move forward and undergo liposuction with stage III kidney disease will be based on a joint effort by your plastic surgeon and your nephrologist.If the indication for liposuction is real and a major change in quality of life would be achieved, then this could possibly be a realistic option if your nephrologist thought the risk would be at an acceptable level. The main drug involved with liposuction is lidocaine. Lidocaine is processed by the liver and not the kidneys. There are many studies showing that lidocaine has little to no toxicity on the kidneys. Please see the link posted below. The article is somewhat technical but summarizes the effects of lidocaine on the kidneys well.There may be many other factors to take into consideration, and a thorough plastic surgeon would rely on the patient's nephrologist to help guide through the decision process.Also, liposuction of small, limited areas, such as the chin and neck, is quite different from high-volume full-body liposuction in regards to stress and overall risks. If the indication for liposuction is weak, meaning there would be only minor improvements in quality of life, then liposuction would most likely not be recommended. In the end, it's a risk-versus-benefit decision. Most plastic surgeons would probably be hesitant.Best of luck,Mats Hagstrom, M.D.