Can Radiesse Be Cut (Diluted) with Something else Before Injecting, or is It Straight from the Tube?

 Botox can be mixed at different ratios, and f it is the same with fillers, specifically Radiesse.

Doctor Answers 11

Diluting Radiesse for Facial Rejuvenation

Yes, I routinely mix Radiesse with lidocaine when injecting the cheeks and midface to achieve a non-surgical midface lift.  This makes injection more comfortable.  Keep in mind, since the lidocaine gets resorbed, the initial result is not the final result.  So the more Radiesse is diluted, the more volume will be lost when the lidocaine goes away.

Paoli Facial Plastic Surgeon
5.0 out of 5 stars 5 reviews

Can Radiesse Be Cut (Diluted) with Something else Before Injecting, or is It Straight from the Tube?

 Yes as it turns out Radiesse is mixed with a small amount of 2% plain lidocaine to make the injections better tolerated.  

Francis R. Palmer, III, MD
Beverly Hills Facial Plastic Surgeon
4.6 out of 5 stars 24 reviews

Cutting Fillers

The only thing that can be done to fillers is to use a special medical instrument that takes some of the filler (at full strength) and solution from a vial of lidocaine putting both together in a new sterile syringe. I would say that this is very rarely used or done, as most manufacturers for fillers now make different sizes of each type of syringe so procedures can be more custom now. The purpose of doing this with the fillers though isn't to "cut" the fillers, it's to add lidocaine, a numbing agent, into them for patient comfort. Additionally, most manufacturers now make fillers with a compounded lidocaine already in them, so this isn't necessary either. Thus, to answer your question, no fillers are not "cut" like Botox so you can only get full strength fillers, but there are different sized syringes! 

F. Victor Rueckl, MD
Las Vegas Dermatologist
4.6 out of 5 stars 17 reviews

Radiesse and Dilution

Radiesse can be mixed with a very small amount of 1% Lidocaine (0.1 mL) for local anesthetic purposes; it is not diluted in the same fashion as Botox.  Radiesse is typically administered in 1.5 mL pre-filled syringes which are single use, single patient treatment vials whereas Botox can be used as a 100 unit multi-use vial.

Stephen Prendiville, MD
Fort Myers Facial Plastic Surgeon
4.8 out of 5 stars 93 reviews

Lidocaine has been a big plus for Radiesse

Great question.  I have been using Radiesse for several years.  It used to be injected without mixing it with anything else.  Even when we would do dental blocks there could be some discomfort using Radiesse.  Now that we mix it with Lidocaine it has made it so much more comfortable for the patient and easier to use for the doctor.

Good Luck

Robert F. Gray, MD, FACS

Robert F. Gray, MD, FACS
Bay Area Facial Plastic Surgeon
3.3 out of 5 stars 13 reviews

Radiesse dilution

I commonly mix Radiesse with a small amount of Lidocaine to help the pain during the procedure.  Not aware of any other reason why this would be done.

Alexander Ovchinsky, MD
New York Facial Plastic Surgeon
4.9 out of 5 stars 30 reviews

Radiesse Pre-mixed with Lidocaine

Radiesse is often pre-mixed with lidocaine prior to injection to help minimize discomfort. Unlike some of the hyaluronic acid fillers, Radiesse is not made with lidocaine built in. 

Channing R. Barnett, MD
New York Dermatologist
4.1 out of 5 stars 8 reviews


It would be unusual to dilute fillers.  Lidocaine (numbing anesthetic) is commonly mixed into Radiesse to make the injection more comfortable for patients, but is not used to dilute it down for the purpose of sharing the filler with other patients.  In my practice, I don't share syringes of fillers amongst patients.

Kimberly Lee, MD
Beverly Hills Facial Plastic Surgeon
5.0 out of 5 stars 13 reviews

Radiesse Can Be Diluted With Lidocaine

Radiesse can be mixed with lidocaine prior to injection.  This gives the benefit:

  • Allowing numbing to injected area for better comfort
  • Thinning out the filler for better sculpting and placement control


Many other fillers, Restylane  and Juvederm for example, come premixed with Lidocaine.

Mark Berkowitz, MD
Sterling Heights Oculoplastic Surgeon
4.7 out of 5 stars 60 reviews

Diluting radiesse to make it more fluid or reduce pain

Radiesse can be mixed with typically a small amount of lidocaine (anesthetic) for a smoother injection flow and to reduce pain. I have routinely done this with great success.

Benjamin Barankin, MD, FRCPC
Toronto Dermatologic Surgeon
4.9 out of 5 stars 49 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.