I have had two large granulomas appear a couple of months after injection. He has injected an enzyme to remove the sculptra and has injected both granulomas - but I'm not sure what with. He used a canula the last time. He mentioned last time that if nothing helps he might inject them with a small amount of chemotherapy (?) This sounds very scary to me. I can live with these if I don't think they will keep "spreading" around my face and will eventually fade. Also I am now on antibiotics.