Hello and thank you for your question. It can. indeed, be very confusing, with all the competing technologies all claiming to be the best. Vaser is a great option for liposuction to treat lipedema, but then so is standard liposuction using a power-assisted device or Body-Jet water-assisted liposuction or Tickle Lipo or any other liposuction system out there. The key to treating lipedema is simply to get the fat out of the treated area. I have had the opportunity to use most liposuction systems out there and I can get great results with any of them. You asked about the differences between systems. All liposuction these days uses "tumescent" fluid for numbing the tissue and to control blood loss. Tumescent fluid is a mixture of lidocaine (numbing agent) and epinephrine (a vasoconstrictor) in either saline or other IV fluid. This solution is pumped or injected into the fatty tissue to be treated to both numb the tissue and to limit bleeding. Vaser liposuction uses an ultrasonically vibrating rod to first loosen the fat and generate heat, which allows for greater skin tightening than one would get using standard liposuction alone. Once the fatty layer has been broken up by the Vaser device, the fat is suctioned out using a suction cannula. Standard liposuction skips the ultrasonic step and goes straight to the suctioning, either using old fashioned elbow grease or using a power-assisted liposuction (PAL) unit, such as a Micro-Aire. Water-assisted liposuction is the same as Body-Jet, which sprays a forceful spray of dilute tumescent solution to loosen the fat while also suctioning at the same time. Tickle Lipo uses a rotating tip, the company refers to as "nutational" energy, to loosen the fat as it is being suctioned. Lastly, there is laser-assisted liposuction, in which laser energy is used to both loosen the fat and to heat the skin for added skin-tightening. Examples of these include Smartipo, CoolLipo, LipoLight, and others. Any of these would work for treating lipedema.I would recommend scheduling more than one consultation with a reputable cosmetic surgeon and be sure to ask about his/her experience treating lipedema patients. Go with the one you feel comfortable with and confident in, regardless of the specific type of liposuction system being offered. I have seen poor results and great results with all of these and the skill of the surgeon is more important than the brand of device used. Best of luck!