Has the new Sculptra mixing time changed?

Hi SB,
Yes, Sculptra can now be mixed immediately prior to use when the proper protocol is used. Many practices still mix their Sculptra days before usage, but in a pinch I can mix it just prior to use. Make sure to choose an expert Sculptra injector should you choose this great treatment. Good luck and be well.
Michael Persky, MD

Short answer: Yes. The current U.S. label allows immediate-use reconstitution: you can mix a vial with 8 mL sterile water (SWFI) for immediate use (optionally add 1 mL of 2% lidocaine just before injection). The label also still permits a 5 mL SWFI reconstitution that must hydrate ≥2 hours and can be stored up to 72 hours before use. FDA Access Data
This change came with an FDA label update that approved higher dilution and immediate-use reconstitution; it wasn’t a fundamental reformulation of the PLLA itself. Practical Dermatology
Bottom line: Your doctor’s “mix the day of treatment” approach is consistent with the updated instructions for use

The formulation for Sculptra has not changed, but the mixing time can vary, depending on the treating physician. I do normally mix my Sculptra the day before I use it but some physicians will mix it just before treating the patient. As long as the vial is well mixed, the result should be the same, no matter when it is reconstituted.

Sculptra is less of a mixture than a suspension. The molecules stimulate your body to produce more tissue, so getting the molecules into the body is key. Once they are suspended in the liquid they are ready to go. It never made sense to wait so long after combining with water, and it still doesn't. The company has now realized that and adjusted their recommendations.

Yes, it is safe to mix Sculptra the day before the procedure. The product is hydrated with sterile water. This can be done one day to several weeks prior to injection.