If hyaluronidase can be used for fibrotic scarring, why can it not be used for collagen overfills by Sculptra?

Question

If hyaluronidase injections can be used on fibrotic scars to break down the connective tissues that give it height and volume, why can they not be used to address areas of overfill caused by Sculptra? I understand that hyaluronidase cannot target the Sculptra PLLA particles, but in cases of overcorrection, can’t the hyaluronidase technically provide some degree of minor volume reduction if it can breakdown components of the ECM? Won't it produce at least some reduction?

Randal Haworth, MD, FACS · Answer

Hyaluronidase is an enzyme that breaks down hyaluronic acid, a substance commonly used in dermal fillers. It is primarily used to correct or dissolve hyaluronic acid-based fillers when there are complications or undesired results, such as overfilling, lumps, or asymmetry. Hyaluronidase works by degrading the hyaluronic acid molecules, allowing them to be absorbed by the body more quickly.

When it comes to Sculptra, it's important to note that Sculptra is not a hyaluronic acid-based filler. Sculptra is composed of poly-L-lactic acid (PLLA) microspheres, which stimulate collagen production in the skin over time. Hyaluronidase does not have any effect on the PLLA particles in Sculptra, as it specifically targets hyaluronic acid.

While hyaluronidase may not directly address or dissolve Sculptra particles, it's worth mentioning that Sculptra typically provides a gradual and subtle increase in volume over a series of treatments. The results of Sculptra injections are not instant, and the volume increase occurs gradually as collagen production is stimulated. If there is an overcorrection or undesired results with Sculptra, the best course of action would be to consult with the injecting physician or a qualified professional to determine the most appropriate solution for your specific case.

They may suggest options such as waiting for the effects of Sculptra to naturally fade over time, or in some cases, they may recommend additional treatments or interventions to address any concerns. It's important to communicate openly with your healthcare provider about your expectations and concerns, as they can provide personalized advice based on your individual circumstances.

I hope this helps,
best of luck !

If hyaluronidase can be used for fibrotic scarring, why can it not be used for collagen overfills by Sculptra?

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If hyaluronidase can be used for fibrotic scarring, why can it not be used for collagen overfills by Sculptra?

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Everything you need to know about Sculptra

Our mission is to create a world where every investment in modern beauty is Worth It.