I appreciate your question. Yes it can. However, the likelihood of the fat transfer taking is unpredictable. The main reason for this is the lack of tissue to graft fat into. For grafted fat to survive it has to be surrounded by vascular tissue. The ankles have very little vascular tissue to graft into since they're mostly made up of skin, bones and tendons etc. Fat is generally successfully grafted into fatty tissues or muscle. Fillers are another option to consider. The best way to assess and give true advice would be an in-person exam. Please see a board-certified plastic surgeon that specializes in aesthetic and restorative plastic surgery. Best of luck! Dr. Schwartz