Will fat transfer fix mental crease?

Hello and thank you for your question.  The
best advice you can receive is from an in-person consultation.  In some patients, fat grafting can be performed in this area to improve a mental crease.   Make sure you specifically look
at before and after pictures of real patients who have had this surgery
performed by your surgeon and evaluate their results.   The most
important aspect is to find a surgeon you are comfortable with. I recommend
that you seek consultation with a qualified board-certified plastic surgeon who
can evaluate you in person.
Best wishes and good luck.
Richard G. Reish, M.D.
Harvard-trained plastic surgeon

Fat will help to soften the crease.  It won't eliminate it completely, but will soften its' appearance.  May need more than one injection of fat. 

Fat grafting to the labiomental fold can be done in one two ways. Fat injection grafting is the most common although the tight tissues of the labiodental fold do not usually bode well for high fat take, more than one injection session may be needed. The second approach is a dermal-fat graft placed intraorally with release of the fold skin on top of the muscle. This is more effective than fat grafting but is also more of a surgery

The Mental Crease is a deep crease that is the result of the action of the mentalis muscle.  Over time this crease gets deeper and deeper.  Filler is usually not enough to improve this crease dramatically.  I My preference is Fat Transfer for this crease and the lines around the lips.  I have been doing fat transfer for over 15 years with permanent results.  In all of my facelift patients I add fat to this area for rejuvenation.  I call it the Peri-Oral Triangle.  This includes the nasolabial folds and marionette lines as well.  Fat transfer allows a great result that dramatically enhances the face.  In my opinion, Fat transfer is the only way to improve the mental crease long term.  You should definitely consider this as an option.  Good luck

fat is the ideal filler for applications such as that. A simple trick is to mix some saline with hyalase and inject a ml or 2 of that. You will get to see what you will get with another form of filler, i.e. fat. Hope that helps, Adam Goodwin

Like the other fillers, fat may soften it a bit, and it may require multiple procedures to see the desired result.