Hello. Thank you for your question. Facelift and CO2 laser resurfacing can absolutely be performed safely at the same time. I have been using this combination for facial rejuvenation for years and have performed thousands of cases combining these two modalities without complication. CO2 laser resurfacing is most useful over the central parts of the face, such as the forehead, periorbital, midface and perioral regions, where wrinkling of the skin is most pronounced due to the actions of the muscles of facial expression. Therefore, the laser energy and depth of penetration can be decreased for blending purposes on the lateral aspects of the face where the skin flap is elevated for the facelift. The blood supply to the facelift skin flap is through the subdermal plexus of vessels, which lies deep to the dermis of the skin. A CO2 laser on lighter settings will not penetrate this deep and should have no impact on blood supply to the skin. I would encourage you to seek a consultation with a board-certified Facial Plastic Surgeon who has extensive experience and expertise in facial rejuvenation and allow them to assess your individual anatomy, concerns and goals, in order to determine the best treatment plan for you. I wish you the best in achieving your aesthetic goals.