Diindolylmethane (DIM) is a compound commonly found in cruciferous vegetables and is often used as a dietary supplement for its potential health benefits. Generally, there is no known contraindication for taking DIM before, during, or after CO2 laser treatments, even when topical lidocaine is used. However, it's important to consider a few factors: Consultation with Your Physician: Always discuss any supplements or medications you are taking with your dermatologist or healthcare provider before undergoing any medical procedure. They can provide personalized advice based on your health history and treatment plan. Potential Interactions: While DIM is generally considered safe, it's crucial to ensure it does not interact with any other medications you might be taking or affect your skin's healing process. Healing and Recovery: Ensure that your dermatologist is aware of all supplements to monitor your skin's response and healing post-procedure. Overall, while taking DIM is likely safe, the best course of action is to get personalized advice from your healthcare provider.