Follow-up Question: How many units of hyaluronidase to dissolve voluma? 6th treatment and it is still there

3 months voluma injected 2 ml. i had vitrase 6-7 times, but the dosages used by doctors were low . 75 ml of voluma got btw 40 to 125 units, 4 days ago 125 units of vitrase, barely any visible effect) 40-50 units per area injected with 50 -55 ml of voluma. hardly working , dose must be too low. how many units can you safely inject without hurting my skin? does the approach of injecting little vitrase work eventually and soften/break down the filler? any voluma reversal experts in ny?

Doctor Answers 3

Follow-up Question: How many units of hyaluronidase to dissolve voluma? 6th treatment and it is still there

Hello Hopexo,

There is no set dose for how much Vitrase (hyaluronidase) to inject to dissolve filler, which is why you have seen such a wide variety used on you.  There is no real risk from a higher dose of Vitrase.  But you have described receiving over 200 units which should have taken care of most of your Voluma.  The fat that you notice some is still present it could represent swelling from your injections.  I would give it at least another 2 weeks before any further injections to let your swelling go down and evaluate to determine if any product is still present.  

I hope this helps and good luck.  


The Woodlands Facial Plastic Surgeon
5.0 out of 5 stars 25 reviews

No set answer

There is no set answer.
Your doctor should consider upping the doses if you are not responding to the Vitrase.

How many units of hyaluronidase to dissolve Voluma

Thank you for your question.  Unfortunately there is no set dosing schedule between hyaluronidase and the hyaluronic acid based dermal fillers.  I have found good results with using between 15-20 units of Vitrase for every tenth of a cc of filler deposited per treatment session.  Hope this helps.

Nelson Castillo, MD
Atlanta Plastic Surgeon
5.0 out of 5 stars 43 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.