Hi pollywolly86,Thanks for your question. It's an interesting one, because I don't think we really know the answer for a given individual. In general, in trials, the fillers have similar duration. Anecdotally, though, some of our patients feel that Restylane lasts longer. Others feel that Juvederm lasts longer. The two fillers also differ in how they feel in the lips. To make matters more confusing, there are now a number of new fillers than can also be used in the lips. I would have a discussion with your provider and tell him/her what you are hoping to achieve with your lip filler. Then he/she can advise you on the best filler for your needs. Good luck!