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One sided crease on cheek (20). Is that a wrinkle or just fat loss?

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Since I remember myself I had a crease on one side of my face. Because it is going down from my eyes it makes me look unproportionally old for my age. I used tretinoin .05 for about a month, but it hadn't really helped. Is that a wrinkle or just fat loss? Because I would like to know how I could solve this, and if laser resurfacing / retin A could help withought using a filler.

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