What is Restylane made of?

Question

Why is Restylane advertised as NASHA (non-animal) when it is made in the lab, from the fermentation of equine (horse) streptococcus? I don't understand! thanks

Sheryl D. Clark, MD, FAAD · Answer

#Restylane is one of the hyaluronic-acid fillers that is derived from bacteria rather than from rooster combs. As such it has no animal proteins. The name of the bacteria has nothing to do with the source of the Restylane.After production, the hyaluronic acid is purified, concentrated, and cross-linked.  There is obviously no bacteria in the final formulation.Hyaluronic acid is a mafor protein of the skin of all mammals. When you inject it into the skin, you are adding more of what is already there.  I hope this clarifies things for you!All the best, Dr. Clark

Michele S. Green, MD · Answer

Restylane is an FDA approved dermal filler that is made from non- animal hyaluronic acid.  It is a safe and easy injection that can plump various areas in the face.  What is important in choosing the correct filler is proper injection technique and matching the patient's anatomical area with the correct type of filler for the best cosmetic result.

Joseph A. Eviatar, MD, FACS · Answer

The answers below are excellent.  What's important in seeking treatment is which of the various fillers are the best for treating the area being treated for the result you desire.  With a tool box full of excellent fillers that are safe and FDA approved, there are many choices so make sure you see an injection specialist who explains to you which filler they'll be using and why that one is the best option for you.All the best and good luck!

Kris M. Reddy, MD, FACS · Answer

Restylane is a FDA-approved dermal filler made
 of a biodegradable, non-animal stabilized hyaluronic acid (NASHA). 
Hyaluronic acid is a natural substance found in all living organisms and
 provides volume and fullness to the skin.
Restylane is a gel of hyaluronic acid generated by Streptococcus 
species of bacteria. It is produced biotechnologically by natural 
fermentation in a sterile laboratory environment. This significantly 
diminishes the risk of transmitting diseases between species or of 
eliciting allergic reactions in patients who are sensitive to common 
foods, such as beef, chicken and eggs. Restylane does not require any 
allergy or skin test prior to injection.

What is Restylane made of?

Answers (4)

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