What is Restylane made of?

Why is Restylane advertised as NASHA (non-animal) when it is made in the lab, from the fermentation of equine (horse) streptococcus? I don't understand! thanks

Doctor Answers 4

Restylane is NASHA

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#Restylane is one of the hyaluronic-acid fillers that is derived from bacteria rather than from rooster combs. As such it has no animal proteins. The name of the bacteria has nothing to do with the source of the Restylane.

After production, the hyaluronic acid is purified, concentrated, and cross-linked.  There is obviously no bacteria in the final formulation.

Hyaluronic acid is a mafor protein of the skin of all mammals. When you inject it into the skin, you are adding more of what is already there.  

I hope this clarifies things for you!

All the best, Dr. Clark

New York Dermatologist
4.7 out of 5 stars 10 reviews

Restylane is made of Hyaluronic Acid

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Restylane is an FDA approved dermal filler that is made from non- animal hyaluronic acid.  It is a safe and easy injection that can plump various areas in the face.  What is important in choosing the correct filler is proper injection technique and matching the patient's anatomical area with the correct type of filler for the best cosmetic result. 


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The answers below are excellent.  What's important in seeking treatment is which of the various fillers are the best for treating the area being treated for the result you desire.  With a tool box full of excellent fillers that are safe and FDA approved, there are many choices so make sure you see an injection specialist who explains to you which filler they'll be using and why that one is the best option for you.

All the best and good luck!

Joseph A. Eviatar, MD, FACS
New York Oculoplastic Surgeon
4.7 out of 5 stars 68 reviews


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Restylane is a FDA-approved dermal filler made of a biodegradable, non-animal stabilized hyaluronic acid (NASHA). Hyaluronic acid is a natural substance found in all living organisms and provides volume and fullness to the skin.

Restylane is a gel of hyaluronic acid generated by Streptococcus species of bacteria. It is produced biotechnologically by natural fermentation in a sterile laboratory environment. This significantly diminishes the risk of transmitting diseases between species or of eliciting allergic reactions in patients who are sensitive to common foods, such as beef, chicken and eggs. Restylane does not require any allergy or skin test prior to injection.

Kris M. Reddy, MD, FACS
West Palm Beach Plastic Surgeon
4.5 out of 5 stars 56 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.