I have been using Profhilo in my Israel satellite facility for more than two years, since it was first approved by the regulatory agency there. I have been using it with extremely gratifying results for nonsurgical face and neck rejuvenation, hands, and for the treatment of upper arm laxity, and periumbilical skin laxity and crepyness. It is a unique, extremely high concentration hyaluronic acid product that is injected via a special technique, in very superficial boluses, and in a specific treatment pattern that takes only a couple of minutes each to treat the entire face, neck, etc. Usually two treatment sessions are required spaced at one month intervals between treatments to achieve a result that typically last six or more months before a maintenance treatment is required. Its purported mechanism of action is via bioremodeling, i.e. the promotion of hydration as well as increasing skin turgor, and I have personally achieved results with this product that I was not able to with ordinary hyaluronic acid skin booster products (also not available in the U.S.). In my Israel facility it is my go-to product for this purpose, and have personally used it for myself and for all appropriate family members. Although I cannot say when it will be available in the States, I can say that I am delighted that I have been able to make it available to my patients abroad. Hope this helps. Best