Botox (as well as the other neuromodulators, Dysport and Xeomin) works by softening the hyperactivity of the muscles of facial expression, such as the frown lines (scowl lines) between the eyebrows, i.e. it works by suppressing dynamic wrinkling or those caused by dynamic muscle movements. However, after years of frowning, most people find that they have developed "etched-in" lines and creases following years of daily muscular activity. These wrinkles are known as static wrinkles, or wrinkles at rest. Fillers are best for elevating and smoothing these. I have personally been performing both treatments for about two decades and it has been reported and my own personal experience confirms that the use of both agents together can achieve a synergistic effect, i.e. one that lasts longer than the effects of either agent when used alone. In my NY practice, I prefer to use Belotero Balance for this purpose, since it possesses little to no tendency to give rise to the unwanted bluish/gray Tyndall Effect when injected superficially in the skin. (In my Israel satellite facility, where a far greater number of regulatory agency approved fillers are available, I typically opt for Teosyal Redensity II or Alaxian FL for this). Injecting this area is not for novice injectors accustomed to treating simple smile lines with ordinary Restylane or Juvederm. Be sure to seek consultation and treatment by a board certified aesthetic physician with experience and expertise and make sure to ask to see his/her before and after photos before agreeing to proceed. Best of luck..
