Difference between hyalourondise and vitrase?

Question

I would like to know the difference between the two and their affect on dissolving HA fillers. I read Vitrase is 200 iu/ml whilst hyalase 1500 iu is 1500 iu/ ml, does that mean they have different concentration and strength? Is a viral of hyalse 1500iu stronger then a viral of vitrase 200iu . or do the equal to the same and vitrase is stronger. Thank you

Hung William Song, MD · Answer

Hyaluronidase is the generic name for an enzyme that can be used to dissolve hyaluronic acid fillers. Vitrase® is one of multiple brands of hyaluronidase. The use of this product to correct HA filler mishaps is considered "off label."  This means that there is no official FDA approve protocol for using hyaluronidase to dissolve fillers. Practiontioners who use this product to dissolve fillers use techniques that they have either developed on their own through years of experience or have learned from other practitioners. The bottom line is, the dose, brand etc. is not what the consumer should be worrying about. What you should really be concerned about is how experienced the injector is in using this product.

Robinson Facial Plastic Surgery - Alpharetta · Answer

The two options you are referring to have various differences. Vitrase is an ovine (sheep) derived enzyme,  with a strength of 200 Units per 1 mL.  Hylenex is a human recombinant enzyme with an activity level of 150 Units per 1mL. They are both a hyaluronidase enzyme that will break down hyaluronic acid. The most commonly used preparation is usually Hylenex, with dosages varying upon amount of filler needed to be dissolved. The strength per mL of either is not reflective upon the effectiveness.  I hope this helps!!
Michelle Giglio, PA-C

Ahad Mahootchi, MD · Answer

Both have the same ingredient. The concentration is different. So the amount of drug will vary by volume used for each. How much someone will need varies in a case way. In general, the number of units used is usually very very small.

F. Victor Rueckl, MD (in memoriam) · Answer

Originally, only Vitrase was available so we were all using that. Hylenex is now what is used more often in the U.S. as that's what's available from most commercial medical supply companies for purchase. None are stronger than others. It's just about the size of the vial. "This answer has been solicited without seeing this patient and 
cannot be held as true medical advice, but only opinion. Seek in-person 
treatment with a trained medical professional for appropriate care."

Difference between hyalourondise and vitrase?

Answers (4)

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