Coughing and Sneezing are natural reflexes for the purpose of getting rid of an irritant in your nose or throat. Although they can generate a lot of force and pressure, they will not affect your Botox treatment.Botox works at the muscles where it is injected. Follow the after care instructions from the person who performed your procedure. Typically this includes avoiding lying flat, exercising, sleeping on your face, and direct pressure/massage on your face for the rest of the day (at least 5 hours). The next day, you can resume all of your normal activities. If you have any questions or concerns, it's best to go back to the person who performed your injection.