Female age 50, wants to improve my look, reduce severals years and look rested. From my picture, what would you suggest?

You would get a substantial improvement from properly placed fillers or the Profound microneedle RF MicroLift. The he most beneficial intervention would be to perform a modified extended deep plane lift. This would give the most natural and most impressive improvement from the lateral brow all the way down to the collar bones.   You can see photos of the AuraLyft to get an idea.  

In my opinion you would benefit from a lower face lift and eyelid lift procedure which can be performed in one sitting. To finish a complete facial rejuvenation I would recommend approximately 6 weeks later a course of laser resurfacing since our face ages not only anatomically by gravity but also the surface of our skin ages as well. Discuss complete rejuvenation with your board certified plastic surgeon.