Hello, Combining microneedling with Tri-Luma can be effective, but it’s important to proceed with caution to avoid skin irritation. Here are some considerations: Skin Sensitivity: Both microneedling and Tri-Luma can increase skin sensitivity. Alternating them on a daily basis may lead to irritation, redness, or peeling, especially if your skin is not accustomed to these treatments. Patch Test: Before starting this regimen, it’s advisable to perform a patch test with both treatments to ensure your skin tolerates them well. Gradual Introduction: Consider starting with a less frequent schedule, such as using the dermaroller twice a week and Tri-Luma on alternate days, to see how your skin responds. Sun Protection: Both treatments can make your skin more susceptible to sun damage. Use a broad-spectrum sunscreen daily to protect your skin. Consult Your Dermatologist: It’s best to discuss your plan with a dermatologist. They can provide personalized advice and may suggest an optimal treatment schedule based on your skin type and concerns. Monitor Your Skin: Pay close attention to how your skin reacts and adjust the frequency of treatments accordingly. If you experience significant irritation, discontinue use and consult with a professional. Best regards,