Once you lose weight and your breasts deflate. Can they ever bounce back from that?

Not on their own! So, gaining weight will not restore your fullness or make you less saggy. However, breast implants with a breast lift can restore you to about 75% of the before saggy look.Best wishes, DR. ALDO 

Hi allison,  Probably not. Most of the time, a patient will need a combination of breast implants with perhaps a breast lift in order to re-shape the breasts. The best thing for you to do is to visit with a Board certified plastic surgeon in your area who has a good experience with breast surgery for an in person exam and a frank discussion of your goals.Best Wishes.,Dr.Christine Rodgers

Without surgery, the simple answer is...NO.But a standard approach that we use to address saggy, deflated breasts includes the following:Placement of a silicone gel implant behind the muscle to replace lost volume and enhance upper pole fullnessShaping of the breast via a Breast Lift to help lift the nipple position, reduce areolar diameter, and help create a tighter, more refined tissue envelope  Your first step should be in consulting in-person with a Board Certified Plastic Surgeon who specializes in breast enhancement surgery (NOT a "Cosmetic Surgeon").  Discuss with him/her your goals and what you would like to accomplish long-termI hope that helps and wish you the very best!-Gregory A Buford MD FACSBoard Certified Plastic Surgeon and Author