How many units of Hylenex to dissolve 1/2 syringe of filler? (Photo)

Thank you for your question. Hyaluronidase(Wydase) is often used to degrade HA filler that have been injected and specifically cross-linked to prevent their natural breakdown.The dosage required is dependent on several factors relating to the HA filler; whether it is particulate or non-particulate, the amount of cross-linking, and the concentration of HA. Different HA fillers have differing physical properties that influence their degradation by hyaluronidase in a time- and dose-dependent manner.  A recent study has shown that Belotero was the fastest to dissolve and Juvederm Voluma®  and Restylane®Lyft were the slowest,  concluding that hyalronic acids with a high concentration of HA, larger particle size, and increased cross-linking increases the durability of the filler.
The literature and my experience sggest many different doses . I usually start with .2 to .5 and then I inject as much hyaluronidase as required to obtain the desired effect rather than following an absolute dosage. So the the amount injected should be titrated to clinical effect.

I hope that helps
Gail Humble MD

A good rule of thumb for hyaluronidase dosing is 1 vial of hyaluronidase for 1 mL of filler. Hope this helps.