Microneedling with Exosomes?

Question

Hello, I am interested in getting microneedling with exosomes. What questions should I ask to discern if I’m getting quality exosomes applied? Do exosomes quality vary a lot amongst manufacturers? Thanks

Anna Chacon, MD, FAAD · Answer

Micro needling with exosomes is a cosmetic procedure that involves creating tiny punctures in the skin and applying exosomes, which are nano-sized vesicles that carry various molecules and signals from cells. Exosomes are believed to have more regenerative potential than platelet-rich plasma (PRP), which is another popular option for micro needling. Exosomes can help reduce inflammation, stimulate collagen production, and improve skin texture and tone.However, not all exosomes are created equal. The quality and purity of exosomes depend on several factors, such as the source, isolation method, storage condition, and characterization technique. Therefore, it is important to ask some questions before you decide to get micro needling with exosomes.Questions to ask:*What is the source of the exosomes? Exosomes can be derived from different types of cells, such as stem cells, platelets, or the placenta.*How are the exosomes isolated and purified? Exosomes can be isolated and purified by various methods, such as ultracentrifugation, filtration, precipitation, chromatography, or microfluidics.
I hope this helps you understand more about micro needling with exosomes and what questions to ask before getting this procedure.

Krishna Vyas, MD, PhD, MHS · Answer

Exosome therapy, or the use of extracellular vesicles, is an emerging and promising technology in regenerative medicine, particularly for skin and soft tissue repair. These nano-sized vesicles carry bioactive molecules that play crucial roles in cellular communication, potentially aiding in tissue regeneration. Preclinical studies, primarily involving animal models, have shown exosomes to be effective in promoting skin healing and restoration, and they hold potential for a variety of applications in plastic and reconstructive surgery. Exosome therapy offers the advantage of being cell-free and ready-to-use, which simplifies its adoption compared to traditional regenerative cell-based therapies. However, no exosome products have been approved by the US FDA yet, and more research is needed to establish clear guidelines for their use. The main considerations for practice utilization include variation in exosome purification, isolation, storage, scalability and reproducibility. 
In the field of regenerative aesthetics, exosomes are gaining attention for their potential in skin rejuvenation and hair restoration. As a minimally invasive option, exosomes offer a promising way to address the underlying causes of skin aging and promote tissue health. While the technology is still in its early stages, initial studies suggest that exosomes can improve skin rejuvenation by enhancing cellular communication and restoring tissue balance. Challenges remain in terms of exosome purification, storage, and reproducibility, and while current research shows safety in humans, there is a lack of consensus on long-term efficacy. Further clinical studies are required to determine which patients will benefit most from exosome therapy and to ensure regulatory compliance before widespread use in aesthetic medicine.Krishna Vyas, MD, PhD, MHSHarvard, Hopkins, & Mayo Clinic Trained Aesthetic Plastic SurgeonNew York, New York

Raffy Karamanoukian, MD, FACS · Answer

Our office has many different treatments for scars depending on the depth of atrophy or hypertrophy. Scars require a combination approach using our HI DEF protocol which uses a combination of lasers, topical scar modulation, and RF treatments to pixelate scars, improve contour, reduce hyperpigmentation, and improve the visibility of the scars so that they are no longer visible in ambient light. Everyone has a unique pattern of scarring and we employ our HIDEF technique to improve texture, color, contour, and topography. We often use a combination of treatments that begin with a careful examination to examine the micro texturing of the acne scars. Atrophic scars and indented  scars can benefit from injectable fillers such as Radiesse, Sculptra, and Restylane with or without subcision to remove tethered scars and atrophic depression. Hyper-redness in scars can be improved with V beam laser, Excel V, BBL, IPL, and Venus RF to improve  the redness and reduce the visibility of deep scars. Fractional Thulium laser and clear & brilliant can also reduce the inflammation and redness of the scar when combined with topical therapy. Fractional lasers such as Fraxel, erbium, and CO2 laser can be combined with radio frequency and also fractional RF to improve textual issues and microtopography. Subcision and TCA cross are also used for deep ice pick scars and narrow valley scars in order to improve the micro texture.  Above all, our combination approach with our clinical nurses and board-certified plastic surgeons can improve the quality of your skin by using at home Melarase creams combined with PRP treatments in our office to improve your skin quality and tone. I recommend getting a formal evaluation with an experienced team of experts in order to reduce your scarring.
 
Finally, hyperpigmentation of scars can be improved with at-home Melarase AM, Melarase PM, and Melapads to help reduce active PIH and melanin deposition.

Best, 
Dr. Karamanoukian
Realself100 Surgeon

Microneedling with Exosomes?

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Microneedling with Exosomes?

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Everything you need to know about Microneedling

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