Easier to remove Restylane than Juvederm?

For unique cases where a variety of modalities could be used to treat the condition, I would suggest an in-person or virtual consultation to develop a custom and effective treatment plan. It is difficult to precisely define the best option without collecting the same information. I suggest reaching out to an expert for a consultation with surgical and non-surgical methods to get a comprehensive option. Best, Dr. Emer.

The particle size may make a difference in how well the different products go away. Recombinant human hyaluronidase (Hylenex) might be better than other forms of the enzyme. Speak with your injector about this option. Warmest regards, Dr. ALDO

Hi There 
In my humble experience it is because the hyalase has not been injected directly in to the filler - it is quite difficult even for advanced injectors to get the hyalase in exactly in the right place.
In the test tube I have looked at very thick fillers - perlane/macrolane/ voluma and thin fillers - they all melt in a few minutes doesn't matter how thick they are...
Kind Regards 
Dr Dinesh Maini 

Hyaluronidase injections are used to dissolve hyaluronic acid fillers in the face. Some injections are easier to dissolve than others.  Juvederm Voluma are thicker cross-linked particles and are more difficult to dissolve than Restylane or Juvederm.  Restylane is usually the easiest to dissolve of all of the fillers.  It also depends on the location and the amount of filler used to inject which can create areas that take more fillers to dissolve the product.  Please consult an expert in facial fillers to address these concerns.  Best, Dr. Green

Hyaluronidase will remove all Hyaluronic acid gels including Restylane  and Juvederm . Since Restylane is a particle  gel compared to Juverderm, I believe it is more susceptible to breaking down with  the hyaluronic acid gel. However it depend  if the Hyaluronidase is injected directly into the area of the product. It also depends on the amount of product injected as well as  its dilution. The more Hyaluronidase that is injected, the better the dissolution of the hyaluronic acid gel.

In an emergency setting, a very large quantity needs to be injected and the sooner the  better.

I am not aware if there are any studies evaluating the difference in speed in breakdown between Restylane and Juvederm. Regardless, both should break down quickly within the first few hours of direct contact with the filler. It is possible after injection to have increased swelling which may make it seem that the filler is still present. Other possibilities is a fluid collection such as blood which will also take time to resolve on its own. Very rarely will patients form calcifications or cysts from inflammation from the injection which will require surgery or needle aspiration to remove. Hope this helps!Johnson C. Lee, MD Plastic Surgery