Movement of the area does no affect the longevity of Botox results but may increase side effects by diffusion of the material
The rate at which Botox dissipates from an area that has been treated depends on many factors. The strength of the muscles that are being treated is one of them. What you call the "metabolism" is the number of enzymes and cellular activity in the area responsible for the breakdown of Botox is another factor and is the strength and the preparation of Botox which has been created pharmacologically. Good luck from New York City