Can you get tear through fillers while using lymecycline and Epiduo gel?

Yes, you can have dermal fillers. Keep in mind, a combination approach will give the most improvement for tear troughs. Fillers, lasers, and microneedling/PRP can improve under the eyes. My patients try to get non surgical treatments to avoid surgery. We use PRP and stem cells there often. I suggest consulting with an expert to develop a treatment plan best suited for your short and long term goals. Best, Dr. Emer

There is no issue or problem with getting fillers in the tear trough or elsewhere while using an oral antibiotic and/or topical acne therapy. Your injecting dermatologist can always guide you on such questions. 

It is fine to get fillers while using antibiotics and Epiduo for acne. It is not recommended to inject fillers where you have an active breakout because of the risk of infection. As long as that precaution is taken there should not be any issues. Good luck!