I'm a female 39 yrs old, I've been taking Isoface for about 2 years now. At age 23 a dermatologist prescribed Roaccutane. I had to stop taking it though because I wanted a baby. I have a healthy 13 year old boy NO birth defects of any kind! I wanted clear skin so I went to a Dr. in Colombia he prescribed Isoface 20mg 3 times/week - my face is COMPLETELY CLEAR! He also said that I can take it for as long as I want as long as I don't plan to have a baby; he's been taking it for 14 years now!