This is a tricky question.Are you having your mastectomies prophylactic ally (no cancer) or because of a present breast cancer?If you currently have breast cancer, I would recommend a mastectomy as soon as cleared from your ob/gyn. You can have tissue expanders (water balloons) placed at the time of surgery in order to allow your body to heal from the pregnancy and return to your pre-pregnancy weight. You can then have your DIEP surgery after you finish your cancer therapy (radiation, chemo, etc).If you are looking to have bilateral mastectomies prophylactically, I would wait at least 6-9 mo until you are back to your pre-pregnancy weight. If you have the option, its best to try and complete your family before having DIEPS, as a pregnancy after a DIEP will be uncomfortable as you are re-stretching skin. Please see a board certified plastic surgeon in consultation.