Thank you for your question! I have injected botox for temporalmandibular joint (TMJ) pain / masseter (jaw muscle) reduction almost daily for 8 years and know that this can be a life changing treatment for patients. I have had optimal results with 20-24 botox units per side every 3-4 months (40-48 units total). Having said that, each patient is different and some do well with higher or lower doses. I recommend that my patients return every 3-4 months for a year to help reduce the size of the masseter and therefore break the habit of clinching and grinding. Some patients do not require any more treatments after a year, and some may need more treatments to help stop the grinding and get pain relief. I hope this information is helpful. Be sure to seek out an expert injector who frequently treats this area. Best of luck!