Thank you for your question. It is safe to use a variety of fillers on the same day. Consider each filler to be a different brush for your physician artist. In some areas, you need a broad brush to create a certain type of effect. Other areas need a fine brush to fill fine lines. Every hyaluronic acid filler (#Restylane, #Juvederm, #Voluma, #Volift, #Vobella, #Perlane, #Belotero) had different properties when injected in the skin. Some of these fillers cause more swelling (greater hydrophilic property), while others provide more lift. Please find a dermatologist or plastic surgeon who has extensive experience with all the current fillers. It is better to have multiple "brushes" to create the perfect effect.Best of luck,Suneel Chilukuri, M.D.Houston, TX