I have scleroderma. Crest. Is Restylane or Juvederm safe for nasolabial folds?

  Thank you for asking your question. Restylane and Juvederm can be used in patients with autoimmune disease. Discuss this with your rheumatologist in case you have any unique  issues. Good luck. 

You can get fillers if you have crest I find the best ones are ones that are reversible and do not build collagen like HA fillers.  Please see an expert.  Best, Dr. Emer.

Hyaluronate-based soft tissue fillers are safe for patients with autoimmune conditions, like C.R.E.S.T.. 
I tell physicians to be aware of increased fibrosis and the obliteration of planes (as part of the pathology of scleroderma spectrum disorders), but aside of this, I believe that patients get good results when their lips and perioral (= around the mouth) areas are treated. In fact, it may even be a nice idea to use some botulinum toxin periorally, to assist with the concentric furrowing.
The advice given to avoid fillers in patients with C.R.E.S.T. was more relevant when collagen was injected, i.e. 20 or so, years ago. Hyaluronic acid fillers are not of animal origin and have very low immunogenicity
Of course, you must understand the potential for 'routine' adverse events and complications, inc. 'delayed hypersensitivity reactions' - ask your physician to discuss these considerations with you. 
The key thing I'd counsel you against is undertaking deep skin-resurfacing.

I would definitely prefer that you consult your rheumatologist before you consider having these facial injections.  There are many times that injections are contraindicated with patients with autoimmune diseases. Please check with your treating physician.  Best, Dr. Green

There is no absolute contraindications to fillers and Botox but check with your rheumatologist to be sure there is no problem in your case. the idea arose decades ago when injectable collagen was invented and autoimmune diseases were called collagen diseases but there has been a great deal of information since then