Thank you for your question. There are fillers in the US that have FDA hand indications. Having said that, any filler that gives good results can be used in an off label area if your injector is familiar with the product. Having said that, I will caution you about using Volbella in the hands if you are looking to replace lost volume. A better choice would be to use Juvederm Ultra Plus or Voluma, but only by an expert injector who can blend the product and match the consistency of your hand soft tissue and skin thickness. I use a cannula to avoid piercing fragile vessels and causing unnecessary bruising. Again, this area should only be trusted to a physician with technical expertise in injecting fillers in hands. Wishing you the best, Dr. Bonakdar