Hello! My name is Jessica, I am a physician assistant, and one of the providers at Aesthetic Skin in Winnetka and Chicago. This is a great question. Yes, it is generally safe to receive Botox injections in the forehead while taking Levothyroxine, a medication commonly prescribed for thyroid hormone replacement. Botox, or botulinum toxin, works locally in the muscles where it is injected and does not interact with thyroid medications in a way that would cause concern. However, it's always important to inform your healthcare provider about all medications you are taking, including Levothyroxine, to ensure they are aware of your complete medical history. I hope this helps and best of luck!