Hello! My name is Jessica, I am a physician assistant, and one of the providers at Aesthetic Skin in Winnetka and Chicago. This is a great question. The horizontal line above the upper lip that you're describing can be challenging to treat, and it’s understandable that you're looking for the most effective approach. Here are some potential treatments and considerations for this specific issue: 1. Botox Muscle Targeting: It’s crucial to ensure that Botox is injected into the correct muscles. The muscle responsible for these horizontal lines is typically the orbicularis oris. If Botox wasn't effective, it might be due to the injection not targeting the right part of the muscle or insufficient dosage. Experienced Injector: Since you mentioned that your clinician hasn't seen this often, seeking out an injector with more experience in treating this specific area could be beneficial. 2. Filler Technique Matters: Using a very small amount of filler with a fine needle and placing it strategically can help reduce the line without creating an unnatural look. Material Choice: Certain fillers are more flexible and might blend better in this delicate area. A hyaluronic acid-based filler, for instance, can offer a more natural result. 3. Other Treatments Microneedling with PRP: This treatment involves tiny needles creating micro-injuries in the skin to stimulate collagen production, and combining it with Platelet-Rich Plasma (PRP) can enhance results. It can help improve skin texture and reduce fine lines over time. Laser Resurfacing: Laser treatments can help improve skin texture and reduce fine lines by stimulating collagen production. Non-ablative lasers are less invasive and can be effective for subtle lines. 4. Skin Care Routine Retinoids: Topical retinoids can help improve skin texture and stimulate collagen production, which might gradually reduce the appearance of fine lines. Hydration and Moisturizers: Keeping the skin well-hydrated can help plump up fine lines and improve overall skin appearance. I hope this helps and best of luck!