5'4, age 33, will 325/350cc on naturally larger boobs be too big? (Photo)

A side photo would help determine your nipple location in relation to your breast fold. Augmentation alone may be sufficient to give you more fullness, however if your nipples are located below your breast fold, a lift may be necessary.

Breast implant selection is best done in person. This gives the surgeon the opportunity to measure your breasts as well as discuss your surgical goals. The two implant sizes you mentioned are conservative to moderate size. It will give you more volume, but the various projections available can impact the final look. You may want to return to your surgeon's office to discuss your options further. Many have sample implants you can "try on" to give you an idea of how you may appear after surgery.

Thank you for your question about breast implants.
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Selecting the most appropriate breast implant size for breast augmentation is a personal decision that ultimately you have to make. An in-person consultation with implant sizing is best.
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It depends on your height, weight and breast base width diameter.
To know what might be right for you, see two or more experienced, board-certified Plastic Surgeons for a complete evaluation to make sure you are a good candidate and that it is safe for you to have breast implant surgery.

I hope this helps.