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Can Hyaluronidase migrate from the area in which it is injected?

September 19, 2018
Asked By:ZPK in Hampton, NH

Here and elsewhere there are reviews about having hyaluronidase injected in a specific region of the face and then experiencing global negative effects. These patients report that hyaluronidase injections into the original treatment area (e.g. just the lips or just the cheekbones) has caused volume loss, sagging, and textural changes in all facial regions (e.g. one patient had the Restylane in her lips dissolved and attributes her under eye hollows to that treatment). Is this at all possible?

Answers (3)

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VOTED MOST HELPFUL
September 21, 2018

Answer: Hyaluronidase & Migration? Dissolving filler

https://carolinafacialplasticsurgery.com/facial-fillers-charlotte/
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Jonathan Kulbersh, MDBoard Certified Facial Plastic Surgeon
(138)
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VOTED MOST HELPFUL
September 21, 2018

Answer: Hyaluronidase & Migration? Dissolving filler

1 person found this helpful
Jonathan Kulbersh, MDBoard Certified Facial Plastic Surgeon
(138)
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MOST RECENT
October 15, 2018

Answer: Hyaluronidase

https://torontosurgery.com/non-surgical/juvederm-filler/
Martin Jugenburg, MDCertified Plastic Surgeon
(877)
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October 15, 2018

Answer: Hyaluronidase

Martin Jugenburg, MDCertified Plastic Surgeon
(877)
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September 21, 2018

Answer: Hyaluronidase facts about reversing fillers--takes a series of treatments

https://jasonemermd.com/
1 person found this helpful
Jason Emer, MDDermatologic Surgeon, Board Certified in Dermatology
(513)
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September 21, 2018

Answer: Hyaluronidase facts about reversing fillers--takes a series of treatments

1 person found this helpful
Jason Emer, MDDermatologic Surgeon, Board Certified in Dermatology
(513)
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Browse related questions

Can hyaluronidase effect the natural tissue?
Jane Olver, MBBS, FRCS says:

If you have hyaluronidase (HyaloFix) into your lips the cross linked hyaluronic acid gel will be hydrolysed and turned to water then absorbed into your body. You also have natural hyaluronate acid (HA) gel within the cells of your body. Your endogenous, meaning produced by you, hyaluronate is i...

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How long will it take for Restylane to dissolve from lip injections and non surgical rhinoplasty?
Glenn Murray, MBBS says:

Restylane usually lasts on average 6 months, however, this is different in every patient. If you get the product dissolved, then this can also dissolve your natural hyaluronic acid. We recommend our patients let the filler naturally dissolve where possible to avoid this.Warm Regards,Dr Glenn...

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Will facial volume restore after Hyaluronidase? Do I have to keep getting more filler for the rest of my life to restore volume?
Raffy Karamanoukian, MD, FACS says:

Longterm filler problems include migration, edema, and nodularity. Filler migration and permanence is a very common problem because there are many different types of HA fillers on the market and each is specified for a specific part of the face. Use of highly cohesive fillers on thin skin may...

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