Can Hyaluronidase migrate from the area in which it is injected?

Question

Here and elsewhere there are reviews about having hyaluronidase injected in a specific region of the face and then experiencing global negative effects. These patients report that hyaluronidase injections into the original treatment area (e.g. just the lips or just the cheekbones) has caused volume loss, sagging, and textural changes in all facial regions (e.g. one patient had the Restylane in her lips dissolved and attributes her under eye hollows to that treatment). Is this at all possible?

Jonathan Kulbersh, MD · Answer

No, this isn't typical with hyaluronidase. It should not migrate and should not cause volume loss or sagging. Hope this helps.

Martin Jugenburg, MD · Answer

Hi. Thank you for your question. It is not likely for Hyaluronidase to migrate to other region of the face and cause volume loss. There might be a temporary natural HA loss but the body replenishes it within few days. Also, having several dissolving sessions with low dose is more ideal.

Jason Emer, MD · Answer

No, it is unlikely hyaluronidase will migrate and it will not impact your natural tissue. It can take a series of treatments to dissolve filler. Best, Dr. Emer

Can Hyaluronidase migrate from the area in which it is injected?

Answers (3)