Congratulations on your decision to proceed with breast reduction surgery. It is one of the most patient pleasing operations we perform. There are no universally accepted "rules of thumb" when it comes to how many cups sizes breasts can be reduced down to. Generally speaking, breasts can be reduced to a very small cup size. The concern with the amount of tissue removed is related to blood flow to the remaining tissue; if too much tissue is removed in one operation the blood flow to the remaining tissue (including nipple/areola) may be compromised. Part of the tissue that is left in place is called the “pedicle"; this segment of tissue is responsible for delivering the blood supply to the nipple/areola tissue. If the pedicle is made too small (in the effort to reduce the breasts as much as possible) then patient will likely have problems with tissue survival. There is also no direct correlation between the amount of tissue removed and the ultimate cup size that a patient will wear after breast reduction surgery. Before undergoing the breast reduction procedure it is very important to communicate your size goals with your surgeon. In my practice, the use of photographs of “goal” pictures (and breasts that are too big or too small) is very helpful. For example, I have found that the use of words such as “natural” or “C or D cup” means different things to different people and therefore prove unhelpful.Also, as you know, cup size varies depending on who makes the bra; therefore, discussing desired cup size may also be inaccurate. Best wishes.