Lines next to lips - is there any way to fix this? (Photo)

Thank you for sharing your photos and your detailed history. The line you’re seeing next to your lips is a common concern and can be due to several overlapping factors. Sometimes, repeated filler treatments and dissolving can slightly alter the natural tissue structure, making certain lines appear more noticeable. These lines can also be the result of natural facial movement, volume loss with age, or skin texture changes.

You’re correct that simply adding more filler into that crease may not always help and, in some cases, could make it look more prominent. Instead, a combination approach often gives the best results. Treatments like microneedling (which you’re already doing), fractional laser, or radiofrequency-based skin tightening can help stimulate collagen and smooth the area. Topical retinoids or medical-grade skincare can also support long-term improvement.

For stubborn lines, other targeted procedures—such as very soft filler placement using a different technique, platelet-rich plasma (PRP), or even resurfacing treatments—may be considered to restore balance without exaggerating the crease.

It’s completely understandable that your eyes go straight to this line, but with the right combination approach, it can definitely be softened over time. You’re already on the right track with microneedling, and with additional supportive treatments, you can likely achieve a smoother and more even look.

Wrinkles around the mouth are best treated by ablative treatments. This would include dermabrasion and CO2 lasers. These treatments remove the top layer of skin and allow it to rejuvenate, removing fine wrinkles. This treatment works best around the mouth.

Hi these Accordion lines can get worst with incorrect placement of thick fillers Bio stimulant filler like diluted radiance filler together with Co2 deep laser would be an option for you

Irregularities around the corners of your mouth is not uncommon.
Sometimes these are referred to as peri oral mounds though they often have slightly different locations. These contour irregularities are poorly understood and inherently difficult to treat.
It is usually not related to a volume excess or deficit, but rather tension from contraction of muscles of facial expression and connective tissue.
These contours can develop and evolve overtime.
It’s not necessarily related to your previous previous fillers.
Fillers may be helpful, but as you mentioned, Kan also make things worse.
The problem is not related, and therefore, volume augmentation is often not the treatment of choice.
I think this condition is difficult and complex and may not be quality treatment that will be consistently successful.
Best,
Mats Hagstrom MD