Lips discoloration can be concerning, especially if it coincides with medication use. Here are some general suggestions that might help, but it's always best to consult with a dermatologist for a personalized assessment: Hydration and Moisturization: Vaseline: Applying Vaseline can help to lock in moisture and protect the lips from further irritation. It's a good option for soothing dry or discolored lips. Honey: Honey has natural healing properties and can be used as a natural moisturizer. Applying a thin layer can help soothe and hydrate your lips. Lip Balm with SPF: Use a lip balm that contains SPF to protect your lips from sun damage, which can exacerbate discoloration. Gentle Exfoliation: Occasionally, gently exfoliate your lips with a soft toothbrush or a sugar scrub to remove dead skin cells. Be gentle to avoid further irritation. Stay Hydrated: Drink plenty of water to keep your skin and lips hydrated from the inside out. Avoid Irritants: Avoid licking your lips or using products with fragrances and dyes that could further irritate sensitive skin. Since you mentioned that the discoloration started after taking amoxicillin, if you suspect an allergic reaction or other side effect, it's important to discuss this with your healthcare provider. They can provide a more accurate diagnosis and suggest appropriate treatments, which may include discontinuing the medication if necessary.