I was wondering if there is any benefit or possible drawback(s) to taking both Spironolactone and DIM. I supplemented with DIM for about a year and saw a great benefit in terms of PMS relief, reduced menstrual cycle pain, energy, and even weight loss. It helped with clearing my acne but wasn't enough, so I was prescribed spironolactone. I eat well & exercise 6x/wk but struggle to lose weight. Can spiro lead to estrogen dominance (& weight gain) - and could DIM help mitigate that?