Are there any benefits or possible drawbacks to taking both Spironolactone and DIM for acne?

Spironolactone and Diindolylmethane (DIM) are both used in the management of hormonal acne, but they work in different ways.
Spironolactone is an androgen blocker. It works by blocking the effect of male hormones, which can contribute to oil production and acne. It has also been used off-label for female pattern hair loss and hirsutism. The most common side effects are increased urination, menstrual irregularities, and breast tenderness. While weight gain is not a common side effect, it can occur in some individuals.
DIM is a natural compound found in cruciferous vegetables that promotes beneficial estrogen metabolism and helps maintain hormonal balance. It is often used by women for symptoms associated with PMS and menopause. As you've mentioned, you've already seen benefits from DIM in terms of PMS relief, reduced menstrual cycle pain, energy, and weight loss.
Combining Spironolactone and DIM could potentially provide a more comprehensive approach to managing your hormonal acne. However, there's limited research on the combined use of these two substances for acne treatment. As with any medication or supplement, there can be potential interactions or side effects.