57 year old starting Accutane - Worried about cystic acne purge

Question

Hi, I am a 57 year old woman who has struggled with cystic acne my entire adult life. I typically will have maybe 2 - 3 cysts at most at a time, but they will get very large and I am constantly going to my derm for steroid injections. I am on 150 mg of spironolactone and taking Seysara daily as well as using a topical tretinoin/spironolactone/clindamycin nightly and Onexton daily. These all help, but I still get cysts. I am very worried about a cystic acne purge when I start Accutane. I know I should start with a low dose, but I am hoping to complete my course of medication as quickly as possible. I weigh 110 pounds

A. David Rahimi, MD · Answer

Dear patient,
In order to reduce the risk of an acne "purge" I would recommend to start with a lower dosage of 20 mg twice a day. After about 4 weeks the dosage can be increased to 40 mg twice a day (adjustment may be needed depending on your weight).
I have found this to be very helpful. Some of my patients can not tolerate the higher dosage and I keep them on the lower dosage for longer than the usual  5 month course. The medication is in your blood stream days after the last pill taken, It is also present in the skin for several months after the last pill. 
I hope this was helpful. Dr David R

Anna Chacon, MD, FAAD · Answer

A  low-dose isotretinoin (Accutane, generic: isotretinoin) regimen is effective and often better tolerated in adults with persistent cystic acne, and starting at a low dose can help minimize the risk and severity of an initial acne "purge." Isotretinoin remains the most clinically effective therapy for long-term remission of severe or treatment-resistant acne, including in older adults.

Initial Worsening ("Purge"): It is common for patients to experience a temporary flare or "purge" of acne lesions, especially cystic lesions, during the first 4–8 weeks of isotretinoin therapy. This is usually self-limited and less severe with lower starting doses.
Low-Dose Strategy: Studies support starting with a low daily dose (e.g., 0.1–0.3 mg/kg/day, which for your weight would be 10–20 mg daily) and gradually increasing as tolerated. This approach reduces the risk of severe flares and side effects, and is particularly appropriate for adult women with sensitive or scar-prone skin.
Course Duration: The total cumulative dose (usually 120–150 mg/kg) is more important than the speed of dose escalation. Completing the course quickly by using higher doses increases the risk of side effects and may worsen the initial flare.
Other Medications: You can continue spironolactone (Aldactone) and topical agents during the initial phase, but antibiotics like Seysara (sarecycline) are usually discontinued once isotretinoin is established, unless your dermatologist advises otherwise.
Long-Term Outlook: Older patients tend to have lower relapse rates after isotretinoin compared to younger patients.

In summary, starting isotretinoin at a low dose and titrating up as tolerated is the best way to minimize the risk of a cystic acne purge, even if it means a longer course. There is no evidence that rushing the course with higher doses improves outcomes, and it may increase both the risk of flares and side effects.

57 year old starting Accutane - Worried about cystic acne purge

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57 year old starting Accutane - Worried about cystic acne purge

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