It’s not uncommon to experience dry or sensitive skin even years after finishing Accutane. Isotretinoin works by shrinking the oil glands, and in some people, these glands don’t fully return to their original activity leading to long-term dryness. To help restore comfort, focus on rebuilding your skin barrier with gentle, fragrance-free, ceramide-rich moisturizers such as CeraVe Healing Ointment, Vanicream Cream, or La Roche-Posay Cicaplast Balm. Using a creamy, non-foaming cleanser and avoiding hot showers can also make a big difference. For very dry areas, applying a thin layer of Vaseline or Aquaphor at night can lock in moisture. Skip exfoliants, alcohol-based toners, and harsh actives while your skin heals, and instead use barrier-supporting creams with ingredients like cholesterol, fatty acids, and ceramides.