What is the best method of removing Xanthomas? I've seen two doctors and each suggest a different treatment. Surgical removal and TCA. I have high cholesterol, which I take medication for. With surgical removal I was told there is a chance it will change the shape of my eye. With TCA I was told it only has a 90% chance of removing them and I would need more than one treatment. I've had these for approx 2 years and they have changed in the last year or so.