Thank you for your question. Depending on the area being treated, both Sculptra and fat grafting can be excellent choices. Generally speaking, on the face, I prefer a combination of Sculptra and hyaluronic acid fillers like Voluma and Vollure (depending on a patient's specific needs) over fat grafting. One of the biggest challenges with fat grafting is that the results can be a little unpredictable - it's not clear at the time of surgery exactly how much of the fat will survive, and whether it will survive evenly. When the fat engrafts evenly, the results are beautiful and longer-lasting than almost any filler product; when it doesn't, the results can appear uneven or lumpy. I have treated a number of patients who have needed corrective fillers and Sculptra to address uneven fat uptake after fat transfer procedures. Sculptra is a collagen stimulating filler, and works with your own body to gradually add subtle volume and lift. On the face, where smaller volumes of product are needed, I think it provides a more reliable result than fat. Sculptra does not "come out of the skin" after 5-6 years, in fact, the Sculptra particles themselves dissolve and are excreted from the body after several months, leaving behind a scaffolding of your own collagen. This isn't to say that there is no place for fat grafting. On the body, in areas where larger volumes are needed (such as buttock augmentation), fat transfer can be an excellent option and far more cost effective than products like Sculptra. In any case, I would recommend scheduling a consultation with a cosmetic dermatologist or plastic surgeon to discuss your concerns. Best of luck!