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The same muscles that make the Nalsolabial Folds worse, called the zygomaticus muscles, also work the corner of the mouth. if you paralyze these muscles with Botox, you will not be able to smile and it will look like you had a stroke. Therefore Botox is not used for this purpose. Instead we use fillers to soften its appearance.
This area would be treated well with fillers, another injectable treatment. Fillers add volume to smooth away creases around the mouth.
Botox and Dysport work by relaxing hyperactive muscles that cause wrinkles, such as the "11" lines between the eyebrows. The creases that go from the nose to the corner of the mouth, often called the "parenthesis" lines, are not caused by hyperactive muscles but rather by tissue sagging. Dermal fillers such as Restylane and Juvederm work best there.
This line is made by the pull of the muscles than make the smile, primarily the zygomaticus major and minor muscles. Individuals who accidentally get treatment into these muscle are generally very unhappy with this treatment result. First, they look like they have had a stroke. Secondly it seems that activity of these muscles is very important to our sense of well being. People get quite depressed if these muscles get weaken by botulinum toxin A treatment. There are treatments to weaken the levator labii alaquae nasi muscle on the side of the nose with the goal of reducing the so-called gummy smile. Generally, I do not believe it is a good idea to do this treatment. The hyaluronic acid fillers are best for this line and the treatment can last well over a year.
The smile folds are best treated by using fillers. Botox has been used by a few skilled physicians to minimize the pulling up of the smile fold but that can affect the mouth and create unwanted appearance of the lip during speech and eating and smiling. It could risk in asymmetry.