Botox seriously didn’t work. What on earth is wrong with me? (Photo)

The number one reason that frown lines don't respond to treatment, if freshly mixed Botox, a lot that is not expired, is ineffective, is not the patient, but that too few units were used. It could also be placement. To not get a relaxation of muscle contraction in the glabella is so rare that before giving up on Botox and wasting money switching brands to Dysport or Xeomin, which all work the same, I would suggest giving the last treatment a full two weeks duration and if there is still no result to have another board certified plastic surgeon or dermatologist inject Botox.  It is not unusual for me to have to inject 20 to 25 or more units of Botox in the glabella for some women who have large muscle bellies  and 35 or more units in some men to get a good relaxation of muscular contraction. 9 or 12 units may not be enough for you. Check to see how many units you had each time.

Thank you for your question. Patients respond to different procedures in uniquely personal ways. If you do not respond positively to Botox, then you, your administer and your board certified facial plastic surgeon should consider other filler options to work towards creating your desired aesthetic appearance.
Best wishes,

Give your second dose of Botox a little longer to work. It can take up to two weeks to see the final results. If you are still not seeing improvement it could be that Botox does not work for you. You can consider other options such as Dysport or Daxxify. Though these are neuromodulators like Botox, they are formulated a little differently and may work for you. I've included a video I hope you find helpful.

There are at least two reasons for this. One is antibodies as previously mentioned. This is not antibodies to the actual Botox molecule, but rather to the protein that carries it. It is for this reason that I switch to other companies products like Dysport or Xeomin in patients who do not have a good reaction to Botox
 Second is injection technique and dosing. We are seeing an increase in non-experts and non-core aesthetic physicians performing these procedures, and such it’s not a wonder that there are sub optimal results. There are large variations in anatomy between individuals, and  my injection points are never the same. This is even in the same patient, as the musculature changes over time (you start recruiting new accessory muscles and the expression and needs change over time). Make sure you see a board-certified cosmetic physician practicing in one of the core specialties for optimal results. 

thanks for your quest
There are some people don’t respond to botox so my suggestin to you after 3 months try dysport Good luck
Dr Wassef, Ottawa 

Some patients have antibodies to Botox, I would contact the office for a follow-up.  If you still have no responded to the Botox injections, I would ask if they have a different neurotoxin that could be used, such as Dysport or Xeomin. Best of luck! Always follow-up with the provider that administers your injections. 

There is a small percentage of people who don't respond to Botox. It might be that the lot of Botox is not working or it wasn't refrigerated correctly, but this is unlikely. You can consider using Dysport, but the active protein in Dysport is the same as Botox. Consider another office/injector too.

Thank you for your question! While there is a possibility that you were under treated(not enough units), there is a small chance that you are immune to the product. There is a minor percentage of the population(1-3%) that Botox is ineffective for. I would recommend trying Dysport or Xeomin to see if other neurotoxins can be effective for you. Please consult an experienced provider to determine the best option. Best of luck!
Katherine Goodwin, PA-C

Botox is a great injection but there are a subset of patients who have antibodies to Botox.  I would recommend that you dry Dysport or Xeomin and see if you have better results.  Please consult an expert in facial cosmetic fillers for the best results.  Best, Dr. Green